Stem cells expand potency and alter tissue fitness by accumulating diverse epigenetic memories | Zendy

Kevin Andrew Uy Gonzales | Zendy; Lisa Polak | Zendy; Irina Matos | Zendy; Matthew Tierney | Zendy; Anita Gola | Zendy; Ellen Wong | Zendy; Nicole R. Infarinato | Zendy; Maria Nikolova | Zendy; Shijing Luo | Zendy; Siqi Liu | Zendy; Jesse Novak | Zendy; Kenneth Lay | Zendy; H. Amalia Pasolli | Zendy; Elaine Fuchs | Zendy

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Stem cells expand potency and alter tissue fitness by accumulating diverse epigenetic memories

Author(s) -

Kevin Andrew Uy Gonzales,

Lisa Polak,

Irina Matos,

Matthew Tierney,

Anita Gola,

Ellen Wong,

Nicole R. Infarinato,

Maria Nikolova,

Shijing Luo,

Siqi Liu,

Jesse Novak,

Kenneth Lay,

H. Amalia Pasolli,

Elaine Fuchs

Publication year - 2021

Publication title -

science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 12.556

H-Index - 1186

eISSN - 1095-9203

pISSN - 0036-8075

DOI - 10.1126/science.abh2444

Subject(s) - epigenetics , stem cell , biology , regeneration (biology) , microbiology and biotechnology , epidermis (zoology) , stem cell theory of aging , inflammation , progenitor cell , neuroscience , immunology , genetics , anatomy , gene , stem cell factor

Stem cells remember Tissue stem cells sense their surroundings, and this perception influences subsequent fate and function. Gonzaleset al . observed that stem cells accumulate epigenetic memories of diverse environmental events (see the Perspective by Hoste). By wounding skin and monitoring the temporal steps involved in mobilizing stem cells of the hair follicle to repair the epidermis, the authors found that stem cells bear memories of their original niche, migration, encounters with inflammation, and adaptation to the new fate and tasks. During homeostasis, immigrant stem cells are functionally and transcriptionally analogous to native cells, but upon future assaults, they unleash discrete epigenetic memories to heighten physiological response and affect tissue fitness. —BAP

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