Regulation of biomolecular condensates by interfacial protein clusters | Zendy

Andrew W. Folkmann | Zendy; Andrea Putnam | Zendy; Chiu Fan Lee | Zendy; Géraldine Seydoux | Zendy

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Regulation of biomolecular condensates by interfacial protein clusters

Author(s) -

Andrew W. Folkmann,

Andrea Putnam,

Chiu Fan Lee,

Géraldine Seydoux

Publication year - 2021

Publication title -

science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 12.556

H-Index - 1186

eISSN - 1095-9203

pISSN - 0036-8075

DOI - 10.1126/science.abg7071

Subject(s) - organelle , biophysics , membrane , microtubule , cytoplasm , pickering emulsion , surface tension , caenorhabditis elegans , emulsion , chemistry , biology , microbiology and biotechnology , biochemistry , physics , quantum mechanics , gene

A Pickering-stabilized intracellular emulsion Pickering emulsions, droplet suspensions stabilized by solid particles, were discovered more than 100 years ago and are well studied in foods, oils, cosmetics, and pharmaceuticals. The particles adsorb to the droplet interface and prevent the emulsion from coarsening. Folkmannet al . report that P granules, biomolecular condensates inCaenorhabditis elegans , are an example of an intracellular Pickering emulsion (see the Perspective by Snead and Gladfelter). Biomolecular condensates are cellular compartments that form without traditional lipid membranes. This work raises the possibility that Pickering agents fulfill the role of membranes in biomolecular condensates. —DJ

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