Developmental and evolutionary dynamics of cis-regulatory elements in mouse cerebellar cells | Zendy

Ioannis Sarropoulos | Zendy; Mari Sepp | Zendy; Robert Frömel | Zendy; Kevin Leiss | Zendy; Nils Trost | Zendy; Evgeny Leushkin | Zendy; Konstantin Okonechnikov | Zendy; Piyush Joshi | Zendy; Peter Giere | Zendy; Lena M. Kutscher | Zendy; Margarida Cardoso-Moreira | Zendy; Stefan M. Pfister | Zendy; Henrik Kaessmann | Zendy

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Developmental and evolutionary dynamics of cis-regulatory elements in mouse cerebellar cells

Author(s) -

Ioannis Sarropoulos,

Mari Sepp,

Robert Frömel,

Kevin Leiss,

Nils Trost,

Evgeny Leushkin,

Konstantin Okonechnikov,

Piyush Joshi,

Peter Giere,

Lena M. Kutscher,

Margarida Cardoso-Moreira,

Stefan M. Pfister,

Henrik Kaessmann

Publication year - 2021

Publication title -

science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 12.556

H-Index - 1186

eISSN - 1095-9203

pISSN - 0036-8075

DOI - 10.1126/science.abg4696

Subject(s) - neurogenesis , cerebellum , chromatin , biology , gene regulatory network , transposase , neuroscience , gene , computational biology , microbiology and biotechnology , genetics , gene expression , genome , transposable element

The cerebellum reveals its genetic programs Gene-regulatory networks govern the development of organs. Sarropouloset al . analyzed mouse cerebellar development in the context of gene-regulatory networks. Single nuclear profiles analyzing chromatin accessibility in about 90,000 cells revealed diversity in progenitor cells and genetic programs guiding cellular differentiation. The footsteps of evolution were apparent in varying constraints on different cell types. —PJH

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