Voltage compartmentalization in dendritic spines in vivo | Zendy

Víctor Hugo Cornejo | Zendy; Netanel Ofer | Zendy; Rafael Yuste | Zendy

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Voltage compartmentalization in dendritic spines in vivo

Author(s) -

Víctor Hugo Cornejo,

Netanel Ofer,

Rafael Yuste

Publication year - 2021

Publication title -

science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 12.556

H-Index - 1186

eISSN - 1095-9203

pISSN - 0036-8075

DOI - 10.1126/science.abg0501

Subject(s) - dendritic spine , neocortex , spine (molecular biology) , dendritic spike , dendrite (mathematics) , depolarization , neuroscience , dendritic filopodia , materials science , biology , biophysics , anatomy , excitatory postsynaptic potential , hippocampal formation , microbiology and biotechnology , geometry , inhibitory postsynaptic potential , mathematics

Dendritic spines’ electrical function? Dendritic spines are small protrusions that cover the dendrites of most neurons in the brain. Their electrical properties are still controversially discussed. Cornejoet al . used an array of techniques to investigate the degree of voltage attenuation by dendritic spine necks in pyramidal neurons of the mouse neocortex. Spines not only synchronously depolarized in response to backpropagating action potentials, but local and transient depolarization also occurred. Isolated depolarization in individual spines reflected localized synaptic activation. A significant voltage gradient between dendritic spine and dendrite indicated that spines may constitute elementary electric compartments. The spine neck resistance is thus not negligible and may substantially contribute to the regulation of synaptic efficacy in the central nervous system. —PRS

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