Diet-regulated production of PDGFcc by macrophages controls energy storage | Zendy

Nehemiah Cox | Zendy; Lucile Crozet | Zendy; Inge R. Holtman | Zendy; Pierre-Louis Loyher | Zendy; Tomi Lazarov | Zendy; Jessica White | Zendy; Elvira Mass | Zendy; E. Richard Stanley | Zendy; Olivier Elemento | Zendy; Christopher K. Glass | Zendy; Frédéric Geissmann | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Diet-regulated production of PDGFcc by macrophages controls energy storage

Author(s) -

Nehemiah Cox,

Lucile Crozet,

Inge R. Holtman,

Pierre-Louis Loyher,

Tomi Lazarov,

Jessica White,

Elvira Mass,

E. Richard Stanley,

Olivier Elemento,

Christopher K. Glass,

Frédéric Geissmann

Publication year - 2021

Publication title -

science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 12.556

H-Index - 1186

eISSN - 1095-9203

pISSN - 0036-8075

DOI - 10.1126/science.abe9383

Subject(s) - adipose tissue , thermogenesis , inflammation , endocrinology , lipodystrophy , insulin resistance , medicine , macrophage , biology , adipose tissue macrophages , overnutrition , obesity , microbiology and biotechnology , immunology , biochemistry , in vitro , human immunodeficiency virus (hiv) , antiretroviral therapy , viral load

Macrophages: key mediators of fat storage Recent work has suggested that macrophages may regulate adiposity, but the mechanisms underlying this process remain unresolved. Coxet al. report that a macrophage-derived growth factor, Pvf3, and its receptor on fat body cells are needed for lipid storage in fruit fly larvae (see the Perspective by O'Brien and Domingos). The mouse Pvf3 ortholog, PDGFcc, was similarly required to store fat in newborn and adult mice. When PDGFcc was blocked or deleted, food intake and absorption were normal, but mice increased their energy expenditure partly due to enhanced brown adipose tissue thermogenesis. PDGFcc was produced exclusively by fat-resident macrophages rather than by those mediating inflammation and insulin resistance. This work may inform future treatments for lipodystrophy, cachexia, and obesity.Science , abe9383, this issue p.eabe9383 ; see also abj5072, p.24

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research