Comment on “Circadian rhythms in the absence of the clock gene Bmal1 ” | Zendy

Elan Ness-Cohn | Zendy; Ravi Allada | Zendy; Rosemary Braun | Zendy

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Comment on “Circadian rhythms in the absence of the clock gene Bmal1 ”

Author(s) -

Elan Ness-Cohn,

Ravi Allada,

Rosemary Braun

Publication year - 2021

Publication title -

science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 12.556

H-Index - 1186

eISSN - 1095-9203

pISSN - 0036-8075

DOI - 10.1126/science.abe9230

Subject(s) - circadian rhythm , oscillating gene , bacterial circadian rhythms , clock , circadian clock , rhythm , biology , neuroscience , genetics , medicine

Rayet al . (Reports, 14 February 2020, p. 800) report apparent transcriptional circadian rhythms in mouse tissues lacking the core clock component BMAL1. To better understand these surprising results, we reanalyzed the associated data. We were unable to reproduce the original findings, nor could we identify reliably cycling genes. We conclude that there is insufficient evidence to support circadian transcriptional rhythms in the absence ofBmal1 .

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