Conserved genetic signatures parcellate cardinal spinal neuron classes into local and projection subsets | Zendy

Peter J. Osseward | Zendy; Neal D. Amin | Zendy; Jeffrey D. Moore | Zendy; Benjamin A. Temple | Zendy; Bianca K. Barriga | Zendy; Lukas C. Bachmann | Zendy; Fernando Beltran | Zendy; Miriam Gullo | Zendy; Robert C. Clark | Zendy; Shawn P. Driscoll | Zendy; Samuel L. Pfaff | Zendy; Marito Hayashi | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Conserved genetic signatures parcellate cardinal spinal neuron classes into local and projection subsets

Author(s) -

Peter J. Osseward,

Neal D. Amin,

Jeffrey D. Moore,

Benjamin A. Temple,

Bianca K. Barriga,

Lukas C. Bachmann,

Fernando Beltran,

Miriam Gullo,

Robert C. Clark,

Shawn P. Driscoll,

Samuel L. Pfaff,

Marito Hayashi

Publication year - 2021

Publication title -

science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 12.556

H-Index - 1186

eISSN - 1095-9203

pISSN - 0036-8075

DOI - 10.1126/science.abe0690

Subject(s) - biology , neuroscience , evolutionary biology , neuron , genetics

Neuronal identities Neurons of the mouse spinal cord can be identified by any of several metrics, including what neurotransmitters they use, what cells they connect to, where they are located, and what neuroprogenitor gave rise to them. Ossewardet al. generated a different metric, genetic signatures, and identified classes of local and projection neurons that were otherwise heterogeneous by other classification systems. With this focus on a cell's genetic signature, its neurotransmitter phenotype, which is accessible by a variety of transcriptional routes, can be seen as a parallel to convergent evolution in development.Science , this issue p.385

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research