Shulin packages axonemal outer dynein arms for ciliary targeting | Zendy

Girish R. Mali | Zendy; Ferdos Abid Ali | Zendy; Clinton K. Lau | Zendy; Farida Begum | Zendy; Jérôme Boulanger | Zendy; Jonathan D. Howe | Zendy; Zhuo A. Chen | Zendy; Juri Rappsilber | Zendy; Mark Skehel | Zendy; Andrew P. Carter | Zendy

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Shulin packages axonemal outer dynein arms for ciliary targeting

Author(s) -

Girish R. Mali,

Ferdos Abid Ali,

Clinton K. Lau,

Farida Begum,

Jérôme Boulanger,

Jonathan D. Howe,

Zhuo A. Chen,

Juri Rappsilber,

Mark Skehel,

Andrew P. Carter

Publication year - 2021

Publication title -

science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 12.556

H-Index - 1186

eISSN - 1095-9203

pISSN - 0036-8075

DOI - 10.1126/science.abe0526

Subject(s) - cilium , ciliogenesis , dynein , flagellum , axoneme , microtubule , microbiology and biotechnology , intraflagellar transport , cytoplasm , ciliate , biology , motile cilium , biophysics , chemistry , genetics , gene

Ciliary motors locked closed by Shulin Motile cilia and flagella are vital cellular organelles with functions that include setting up the left-right body axis, clearing airways of mucus, and driving single-cell movements. Cilia beating is powered by arrays of dynein motors, the key force generators being the outer dynein arm (ODA) complexes. Using the protozoanTetrahymena , Maliet al. identified a factor, which they name Shulin, that binds newly synthesized ODAs. Cryo–electron microscopy revealed how Shulin locks the dynein motors together by shutting off motor activity and facilitating delivery of ODAs from the cytoplasm to their final position in the cilia.Science , this issue p.910

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