Cryo-EM structure of the B cell co-receptor CD19 bound to the tetraspanin CD81 | Zendy

Katherine J. Susa | Zendy; Shaun Rawson | Zendy; Andrew C. Kruse | Zendy; Stephen C. Blacklow | Zendy

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Cryo-EM structure of the B cell co-receptor CD19 bound to the tetraspanin CD81

Author(s) -

Katherine J. Susa,

Shaun Rawson,

Andrew C. Kruse,

Stephen C. Blacklow

Publication year - 2021

Publication title -

science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 12.556

H-Index - 1186

eISSN - 1095-9203

pISSN - 0036-8075

DOI - 10.1126/science.abd9836

Subject(s) - tetraspanin , cd81 , cd19 , receptor , chemistry , microbiology and biotechnology , cell , biology , virology , biochemistry , hepatitis c virus , virus

A key complex in B cell activation A core component of the immune system are B cells, which are activated by infection and then mature to provide long-lived immunity. Activation is initiated when a cell surface B cell receptor, in association with its coreceptor, recognizes an antigen. Susaet al. report a structure of the B cell coreceptor signaling subunit CD19 in complex with CD81, a key regulator. CD81 alone binds to cholesterol, but the conformational changes associated with binding to CD19 occlude the cholesterol-binding pocket. Regulating cholesterol binding could play a role in the activation mechanism. The structure also provides a basis for the design of immunotherapies.Science , this issue p.300

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