Open AccessCerebellar nuclei evolved by repeatedly duplicating a conserved cell-type set
Author(s) -
Justus M. Kebschull,
Ethan B. Richman,
Noam Ringach,
Drew Friedmann,
Eddy Albarran,
Sai Saroja Kolluru,
Robert C. Jones,
William E. Allen,
Ying Wang,
Seung Woo Cho,
Huaijun Zhou,
Jun Ding,
Howard Y. Chang,
Karl Deisseroth,
Stephen R. Quake,
Liqun Luo
Publication year - 2020
Publication title -
science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 12.556
H-Index - 1186
eISSN - 1095-9203
pISSN - 0036-8075
DOI - 10.1126/science.abd5059
Subject(s) - cerebellum , neuroscience , excitatory postsynaptic potential , biology , nucleus , cell type , neuron , inhibitory postsynaptic potential , anatomy , cell , genetics
Cerebellar evolution Cerebellar nuclei, substructures of the cerebellum, transfer information from the cerebellum to other parts of the brain. Using single-cell transcriptomics, Kebschullet al. have now identified a conserved pattern of cerebellar nuclei structure that has been repeated through evolution (see the Perspective by Hatten). Ranging from mice to chickens to humans, cerebellar nuclei are made up of region-specific excitatory neurons and region-invariant inhibitory neurons. In humans, a facet connecting the cerebellum to the frontal cortex is enhanced.Science , this issue p.eabd5059 ; see also p.1411
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