Tubulin glycylation controls axonemal dynein activity, flagellar beat, and male fertility | Zendy

Sudarshan Gadadhar | Zendy; Gonzalo Alvarez Viar | Zendy; Jan N. Hansen | Zendy; An Gong | Zendy; Aleksandr Kostarev | Zendy; Côme IalyRadio | Zendy; Sophie Leboucher | Zendy; Marjorie Whitfield | Zendy; Ahmed Ziyyat | Zendy; Aminata Touré | Zendy; Luis Álvarez | Zendy; Gaia Pigino | Zendy; Carsten Janke | Zendy

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Tubulin glycylation controls axonemal dynein activity, flagellar beat, and male fertility

Author(s) -

Sudarshan Gadadhar,

Gonzalo Alvarez Viar,

Jan N. Hansen,

An Gong,

Aleksandr Kostarev,

Côme IalyRadio,

Sophie Leboucher,

Marjorie Whitfield,

Ahmed Ziyyat,

Aminata Touré,

Luis Álvarez,

Gaia Pigino,

Carsten Janke

Publication year - 2021

Publication title -

science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 12.556

H-Index - 1186

eISSN - 1095-9203

pISSN - 0036-8075

DOI - 10.1126/science.abd4914

Subject(s) - flagellum , dynein , cilium , axoneme , microtubule , biology , microbiology and biotechnology , organelle , tubulin , motile cilium , sperm , cytoskeleton , dynein atpase , genetics , cell , gene

Glycylation regulates axonemal dyneins Physiological functions of the microtubule cytoskeleton are expected to be regulated by a variety of posttranslational tubulin modifications. For instance, tubulin glycylation is almost exclusively found in cilia and flagella, but its role in the function of these organelles remains unclear. Gadadharet al. now demonstrate in mice that glycylation, although nonessential for the formation of cilia and flagella, coordinates the beat waveform of sperm flagella. This activity is a prerequisite for progressive sperm swimming and thus for male fertility. At the ultrastructural level, lack of glycylation perturbed the distribution of axonemal dynein conformations, which may explain the observed defects in flagellar beat.Science , this issue p.eabd4914

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