Recapitulation of HIV-1 Env-antibody coevolution in macaques leading to neutralization breadth | Zendy

Ryan S. Roark | Zendy; Hui Li | Zendy; Wilton B. Williams | Zendy; Hema Chug | Zendy; Rosemarie D. Mason | Zendy; Jason Gorman | Zendy; Shuyi Wang | Zendy; Fang-Hua Lee | Zendy; Juliette Rando | Zendy; Mattia Bonsignori | Zendy; Kwan-Ki Hwang | Zendy; Kevin O. Saunders | Zendy; Kevin Wiehe | Zendy; M. Anthony Moody | Zendy; Peter Hraber | Zendy; Kshitij Wagh | Zendy; Elena E. Giorgi | Zendy; Ronnie M. Russell | Zendy; Frédéric BibolletRuche | Zendy; Weimin Liu | Zendy; Andrew Connell | Zendy; Andrew G. Smith | Zendy; Julia C. DeVoto | Zendy; Alexander I. Murphy | Zendy; Jessica G. Smith | Zendy; Wenge Ding | Zendy; Chengyan Zhao | Zendy; Neha Chohan | Zendy; Maho Okumura | Zendy; Christina Rosario | Zendy; Yu Ding | Zendy; Emily Lindemuth | Zendy; Anya M. Bauer | Zendy; Katharine J. Bar | Zendy; David R. Ambrozak | Zendy; Cara W. Chao | Zendy; GwoYu Chuang | Zendy; Hui Geng | Zendy; Bob C. Lin | Zendy; Mark K. Louder | Zendy; Richard Nguyen | Zendy; Baoshan Zhang | Zendy; Mark G. Lewis | Zendy; D.D. Raymond | Zendy; Nicole A. DoriaRose | Zendy; Chaim A. Schramm | Zendy; Daniel C. Douek | Zendy; Mario Roederer | Zendy; Thomas B. Kepler | Zendy; Garnett Kelsoe | Zendy; John R. Mascola | Zendy; Peter D. Kwong | Zendy; Bette Korber | Zendy; Stephen C. Harrison | Zendy; Barton F. Haynes | Zendy; Beatrice H. Hahn | Zendy; George M. Shaw | Zendy

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Recapitulation of HIV-1 Env-antibody coevolution in macaques leading to neutralization breadth

Author(s) -

Ryan S. Roark,

Hui Li,

Wilton B. Williams,

Hema Chug,

Rosemarie D. Mason,

Jason Gorman,

Shuyi Wang,

Fang-Hua Lee,

Juliette Rando,

Mattia Bonsignori,

Kwan-Ki Hwang,

Kevin O. Saunders,

Kevin Wiehe,

M. Anthony Moody,

Peter Hraber,

Kshitij Wagh,

Elena E. Giorgi,

Ronnie M. Russell,

Frédéric BibolletRuche,

Weimin Liu,

Andrew Connell,

Andrew G. Smith,

Julia C. DeVoto,

Alexander I. Murphy,

Jessica G. Smith,

Wenge Ding,

Chengyan Zhao,

Neha Chohan,

Maho Okumura,

Christina Rosario,

Yu Ding,

Emily Lindemuth,

Anya M. Bauer,

Katharine J. Bar,

David R. Ambrozak,

Cara W. Chao,

GwoYu Chuang,

Hui Geng,

Bob C. Lin,

Mark K. Louder,

Richard Nguyen,

Baoshan Zhang,

Mark G. Lewis,

D.D. Raymond,

Nicole A. DoriaRose,

Chaim A. Schramm,

Daniel C. Douek,

Mario Roederer,

Thomas B. Kepler,

Garnett Kelsoe,

John R. Mascola,

Peter D. Kwong,

Bette Korber,

Stephen C. Harrison,

Barton F. Haynes,

Beatrice H. Hahn,

George M. Shaw

Publication year - 2020

Publication title -

science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 12.556

H-Index - 1186

eISSN - 1095-9203

pISSN - 0036-8075

DOI - 10.1126/science.abd2638

Subject(s) - neutralization , coevolution , antibody , virology , human immunodeficiency virus (hiv) , biology , virus , evolutionary biology , immunology

Convergent HIV evolution across species Human immunodeficiency virus (HIV) has a highly diverse envelope protein that it uses to target human cells, and the complexity of the viral envelope has stymied vaccine development. Roarket al. report that the immediate and short-term evolutionary potential of the HIV envelope is constrained because of a number of essential functions, including antibody escape. Consequently, when introduced into humans as HIV or into rhesus macaque monkeys as chimeric simian-human immunodeficiency virus, homologous envelope glycoproteins appear to exhibit conserved patterns of sequence evolution, in some cases eliciting broadly neutralizing antibodies in both hosts. Conserved patterns of envelope variation and homologous B cell responses in humans and monkeys represent examples of convergent evolution that may serve to guide HIV vaccine development.Science , this issue p.eabd2638

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