QSER1 protects DNA methylation valleys from de novo methylation | Zendy

Gary Dixon | Zendy; Heng Pan | Zendy; Dapeng Yang | Zendy; Bess P. Rosen | Zendy; Therande Jashari | Zendy; Nipun Verma | Zendy; Julián Pulecio | Zendy; Inbal Caspi | Zendy; Kihyun Lee | Zendy; Stephanie Stransky | Zendy; Abigail Glezer | Zendy; Chang Liu | Zendy; Marco A. Rivas | Zendy; Ritu Kumar | Zendy; Yahui Lan | Zendy; Ingrid Torregroza | Zendy; Chuan He | Zendy; Simone Sidoli | Zendy; Todd Evans | Zendy; Olivier Elemento | Zendy; Danwei Huangfu | Zendy

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QSER1 protects DNA methylation valleys from de novo methylation

Author(s) -

Gary Dixon,

Heng Pan,

Dapeng Yang,

Bess P. Rosen,

Therande Jashari,

Nipun Verma,

Julián Pulecio,

Inbal Caspi,

Kihyun Lee,

Stephanie Stransky,

Abigail Glezer,

Chang Liu,

Marco A. Rivas,

Ritu Kumar,

Yahui Lan,

Ingrid Torregroza,

Chuan He,

Simone Sidoli,

Todd Evans,

Olivier Elemento,

Danwei Huangfu

Publication year - 2021

Publication title -

science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 12.556

H-Index - 1186

eISSN - 1095-9203

pISSN - 0036-8075

DOI - 10.1126/science.abd0875

Subject(s) - dna methylation , biology , rna directed dna methylation , methylation , epigenomics , epigenetics , genetics , dna , gene , microbiology and biotechnology , gene expression

Screen identifies demethylation regulator DNA methylation was one of the first epigenetic mechanisms discovered, but there is a limited understanding of its regulation and dysregulation in the context of development and disease. Dixonet al. performed a genome-wide CRISPR-Cas9 screen in human embryonic stem cells to identify DNA methylation regulators (see the Perspective by Gu and Goodell). A top screen hit, QSER1, proved to be essential for maintaining low methylation at DNA methylation valleys, which overlap with developmental genes and broad H3K27me3 and EZH2 peaks. Mechanistic examination revealed that QSER1 and the demethylating enzyme TET1 cooperate to safeguard developmental programs from de novo methylation by the enzyme DNMT3.Science , this issue p.eabd0875 ; see also p.128

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