A ubiquitin ligase mediates target-directed microRNA decay independently of tailing and trimming | Zendy

Jaeil Han | Zendy; Collette A. LaVigne | Zendy; Benjamin T. Jones | Zendy; He Zhang | Zendy; Frank A Gillett | Zendy; Joshua T. Mendell | Zendy

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A ubiquitin ligase mediates target-directed microRNA decay independently of tailing and trimming

Author(s) -

Jaeil Han,

Collette A. LaVigne,

Benjamin T. Jones,

He Zhang,

Frank A Gillett,

Joshua T. Mendell

Publication year - 2020

Publication title -

science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 12.556

H-Index - 1186

eISSN - 1095-9203

pISSN - 0036-8075

DOI - 10.1126/science.abc9546

Subject(s) - ubiquitin ligase , microrna , cullin , microbiology and biotechnology , argonaute , ubiquitin , biology , dna ligase , chemistry , rna interference , genetics , rna , gene

Turning the tables on microRNA decay MicroRNAs help to regulate many genes in animal cells. Each microRNA associates with an Argonaute (AGO) protein, forming a complex in which the microRNA pairs with a messenger RNA (mRNA) target and AGO recruits factors that accelerate mRNA decay. However, for some unusual targets, the reverse occurs: Pairing to the target recruits factors that accelerate microRNA decay rather than degradation of the mRNA. Working independently, Shiet al. and Hanet al. elucidate the mechanism of this phenomenon. They found that pairing to the unusual targets recruits a ubiquitin ligase that causes degradation of AGO, thereby exposing the microRNA to cellular nucleases. Mutating the ubiquitin ligase in diverse animals and cell types deregulates numerous microRNAs, implying that this phenomenon is widely deployed to sculpt microRNA levels.Science , this issue p.eabc9359 , p.eabc9546

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