Comment on “Ancient origins of allosteric activation in a Ser-Thr kinase” | Zendy

Yeonwoo Park | Zendy; Jaeda Patton | Zendy; Georg Hochberg | Zendy; Joseph W. Thornton | Zendy

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Comment on “Ancient origins of allosteric activation in a Ser-Thr kinase”

Author(s) -

Yeonwoo Park,

Jaeda Patton,

Georg Hochberg,

Joseph W. Thornton

Publication year - 2020

Publication title -

science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 12.556

H-Index - 1186

eISSN - 1095-9203

pISSN - 0036-8075

DOI - 10.1126/science.abc8301

Subject(s) - allosteric regulation , kinase , chemistry , microbiology and biotechnology , biology , enzyme , biochemistry

Hadzipasicet al . (Reports, 21 February 2020, p. 912) used ancestral sequence reconstruction to identify historical sequence substitutions that putatively caused Aurora kinases to evolve allosteric regulation. We show that their results arise from using an implausible phylogeny and sparse sequence sampling. Addressing either problem reverses their inferences: Allostery and the amino acids that confer it were not gained during the diversification of eukaryotes but were lost in a subgroup of Fungi.

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