Structural basis of antagonizing the vitamin K catalytic cycle for anticoagulation | Zendy

Shixuan Liu | Zendy; Shuang Li | Zendy; Guomin Shen | Zendy; N. Sukumar | Zendy; Andrzej M. Krezel | Zendy; Weikai Li | Zendy

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Structural basis of antagonizing the vitamin K catalytic cycle for anticoagulation

Author(s) -

Shixuan Liu,

Shuang Li,

Guomin Shen,

N. Sukumar,

Andrzej M. Krezel,

Weikai Li

Publication year - 2020

Publication title -

science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 12.556

H-Index - 1186

eISSN - 1095-9203

pISSN - 0036-8075

DOI - 10.1126/science.abc5667

Subject(s) - vitamin k epoxide reductase , vitamin k , vitamin , warfarin , chemistry , enzyme , substrate (aquarium) , reductase , vitamin c , epoxide , pharmacology , biochemistry , catalysis , stereochemistry , combinatorial chemistry , medicine , biology , cytochrome p450 , cyp2c9 , ecology , atrial fibrillation

Anticoagulants take over In its fully reduced form, vitamin K helps to catalyze an oxidation reaction essential for blood coagulations, but it must be regenerated in each reaction through reduction. Liuet al. determined the structures of the enzyme responsible, vitamin K epoxide reductase, bound to an oxidized vitamin K substrate or with anticoagulants, including the widely prescribed drug warfarin. Understanding how these molecules bind and inhibit explains some variations in the therapeutic response as well as resistance for anticoagulants used in pest control.Science , this issue p.43

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