Primary exposure to SARS-CoV-2 protects against reinfection in rhesus macaques | Zendy

Wei Deng | Zendy; Linlin Bao | Zendy; Jiangning Liu | Zendy; Chong Xiao | Zendy; Jiayi Liu | Zendy; Jing Xue | Zendy; Qi Lv | Zendy; Feifei Qi | Zendy; Hong Gao | Zendy; Pin Yü | Zendy; Yanfeng Xu | Zendy; Yajin Qu | Zendy; Fengdi Li | Zendy; Zhiguang Xiang | Zendy; Haisheng Yu | Zendy; Shuran Gong | Zendy; Mingya Liu | Zendy; Guanpeng Wang | Zendy; Shunyi Wang | Zendy; Zhiqi Song | Zendy; Ying Liu | Zendy; Wenjie Zhao | Zendy; Yunlin Han | Zendy; Linna Zhao | Zendy; Xing Liu | Zendy; Qiang Wei | Zendy; Chuan Qin | Zendy

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Primary exposure to SARS-CoV-2 protects against reinfection in rhesus macaques

Author(s) -

Wei Deng,

Linlin Bao,

Jiangning Liu,

Chong Xiao,

Jiayi Liu,

Jing Xue,

Qi Lv,

Feifei Qi,

Hong Gao,

Pin Yü,

Yanfeng Xu,

Yajin Qu,

Fengdi Li,

Zhiguang Xiang,

Haisheng Yu,

Shuran Gong,

Mingya Liu,

Guanpeng Wang,

Shunyi Wang,

Zhiqi Song,

Ying Liu,

Wenjie Zhao,

Yunlin Han,

Linna Zhao,

Xing Liu,

Qiang Wei,

Chuan Qin

Publication year - 2020

Publication title -

science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 12.556

H-Index - 1186

eISSN - 1095-9203

pISSN - 0036-8075

DOI - 10.1126/science.abc5343

Subject(s) - rhesus macaque , clearance , immunity , virology , immunology , macaque , covid-19 , immune system , biology , herd immunity , coronavirus , virus , medicine , disease , vaccination , infectious disease (medical specialty) , paleontology , urology

Coronavirus disease 2019 (COVID-19), which is caused by infection with the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has become a global pandemic. It is unclear whether convalescing patients have a risk of reinfection. We generated a rhesus macaque model of SARS-CoV-2 infection that was characterized by interstitial pneumonia and systemic viral dissemination mainly in the respiratory and gastrointestinal tracts. Rhesus macaques reinfected with the identical SARS-CoV-2 strain during the early recovery phase of the initial SARS-CoV-2 infection did not show detectable viral dissemination, clinical manifestations of viral disease, or histopathological changes. Comparing the humoral and cellular immunity between primary infection and rechallenge revealed notably enhanced neutralizing antibody and immune responses. Our results suggest that primary SARS-CoV-2 exposure protects against subsequent reinfection in rhesus macaques.

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