Genomic, epigenomic, and biophysical cues controlling the emergence of the lung alveolus | Zendy

Jarod A. Zepp | Zendy; Michael P. Morley | Zendy; Claudia Loebel | Zendy; Madison M. Kremp | Zendy; Fatima Chaudhry | Zendy; Maria C. Basil | Zendy; John P. Leach | Zendy; Derek C. Liberti | Zendy; Terren K. Niethamer | Zendy; Yun Ying | Zendy; Sowmya Jayachandran | Zendy; Apoorva Babu | Zendy; Su Zhou | Zendy; David B. Frank | Zendy; Jason A. Burdick | Zendy; Edward E. Morrisey | Zendy

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Genomic, epigenomic, and biophysical cues controlling the emergence of the lung alveolus

Author(s) -

Jarod A. Zepp,

Michael P. Morley,

Claudia Loebel,

Madison M. Kremp,

Fatima Chaudhry,

Maria C. Basil,

John P. Leach,

Derek C. Liberti,

Terren K. Niethamer,

Yun Ying,

Sowmya Jayachandran,

Apoorva Babu,

Su Zhou,

David B. Frank,

Jason A. Burdick,

Edward E. Morrisey

Publication year - 2021

Publication title -

science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 12.556

H-Index - 1186

eISSN - 1095-9203

pISSN - 0036-8075

DOI - 10.1126/science.abc3172

Subject(s) - lung , microbiology and biotechnology , myofibroblast , cell , stromal cell , biology , progenitor cell , epigenomics , breathing , stem cell , pathology , anatomy , genetics , medicine , cancer research , gene expression , gene , dna methylation , fibrosis

Transitioning lung for postnatal life The lung is a complex organ composed of multiple cell types, and its alveolus serves as the functional unit of gas exchange. The alveolar type 1 cell (AT1) serves as an active signaling hub in the developing and postnatal mouse and human lung. Zeppet al. generated a comprehensive single-cell atlas of the developing murine lung and identified cell differentiation and cell-to-cell communication as the lung transitions to air breathing. The AT1 cells spatially aligned with stromal progenitors and formed a signaling hub that preferentially communicated with a transient, force-exerting, myofibroblast through signaling factors including Shh and Wnts to actively remodel the alveolus after the transition to air breathing.Science , this issue p.eabc3172

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