Lipid presentation by the protein C receptor links coagulation with autoimmunity | Zendy

Nadine MüllerCalleja | Zendy; Anne Hollerbach | Zendy; Jennifer Royce | Zendy; Svenja Ritter | Zendy; Denise Pedrosa | Zendy; Thati Madhusudhan | Zendy; Sina Teifel | Zendy; Myriam Meineck | Zendy; Friederike Häuser | Zendy; Antje Canisius | Zendy; ThanhSon Nguyen | Zendy; Johannes Braun | Zendy; Kai Bruns | Zendy; Anna Etzold | Zendy; Ulrich Zechner | Zendy; Susanne Strand | Zendy; Markus P. Radsak | Zendy; Dennis Strand | Zendy; Jian-Ming Gu | Zendy; Julia WeinmannMenke | Zendy; Charles T. Esmon | Zendy; Luc Teyton | Zendy; Karl J. Lackner | Zendy; Wolfram Ruf | Zendy

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Lipid presentation by the protein C receptor links coagulation with autoimmunity

Author(s) -

Nadine MüllerCalleja,

Anne Hollerbach,

Jennifer Royce,

Svenja Ritter,

Denise Pedrosa,

Thati Madhusudhan,

Sina Teifel,

Myriam Meineck,

Friederike Häuser,

Antje Canisius,

ThanhSon Nguyen,

Johannes Braun,

Kai Bruns,

Anna Etzold,

Ulrich Zechner,

Susanne Strand,

Markus P. Radsak,

Dennis Strand,

Jian-Ming Gu,

Julia WeinmannMenke,

Charles T. Esmon,

Luc Teyton,

Karl J. Lackner,

Wolfram Ruf

Publication year - 2021

Publication title -

science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 12.556

H-Index - 1186

eISSN - 1095-9203

pISSN - 0036-8075

DOI - 10.1126/science.abc0956

Subject(s) - autoimmunity , immunology , antiphospholipid syndrome , endothelial protein c receptor , coagulation , lupus anticoagulant , tissue factor , receptor , internalization , antibody , biology , medicine , thrombin , biochemistry , platelet

A lipid-protein autoimmunity target Several autoimmune diseases, including systemic lupus erythematosus and primary antiphospholipid syndrome, are characterized by the presence of antiphospholipid antibodies (aPLs). These molecules can activate the complement and coagulation cascades, which contributes to pathologies such as thrombosis, stroke, and pregnancy complications. Müller-Callejaet al. found that endothelial protein C receptor (EPCR) in complex with lysobisphosphatidic acid (LBPA) is the cell-surface target for aPL and mediates its internalization (see the Perspective by Kaplan). aPL binding to EPCR-LBPA resulted in the activation of tissue factor–mediated coagulation and interferon-α production by dendritic cells. Interferon-α, in turn, fueled the expansion of B1a cells, which secrete aPLs. The specific blockade of this target in mice inhibited the development of aPL autoimmunity, offering hope for future therapies for these conditions.Science , this issue p.eaay1833 ; see also p.1100

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