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Cryptic transmission of SARS-CoV-2 in Washington state
Author(s) -
Trevor Bedford,
Alexander L. Greninger,
Pavitra Roychoudhury,
Lea M. Starita,
Michael Famulare,
MeeiLi Huang,
Arun Kumar Nalla,
Gregory Pepper,
Adam Reinhardt,
Hong Xie,
Lasata Shrestha,
Truong N. Nguyen,
Amanda Adler,
Elisabeth Brandstetter,
Shari Cho,
Danielle Giroux,
Peter D. Han,
Kairsten Fay,
Chris Frazar,
Misja Ilcisin,
Kirsten Lacombe,
Jover Lee,
Anahita Kiavand,
M Richardson,
Thomas R. Sibley,
Melissa Truong,
Caitlin R. Wolf,
Deborah A. Nickerson,
Mark J. Rieder,
Janet A. Englund,
James Hadfield,
Emma B. Hodcroft,
John Huddleston,
Louise H. Moncla,
Nicola F. Müller,
Richard A. Neher,
Xianding Deng,
Wei Gu,
Scot Federman,
Charles Y. Chiu,
Jeffrey S. Duchin,
Romesh Gautom,
Geoff Melly,
Brian Hiatt,
Philip Dykema,
Scott Lindquist,
Krista Queen,
Ying Tao,
Anna Uehara,
Suxiang Tong,
Duncan MacCannell,
Gregory L. Armstrong,
Geoffrey S. Baird,
Helen Y. Chu,
Jay Shendure,
Keith R. Jerome,
Michael Boeckh,
Barry R. Lutz,
Matthew Thompson,
Michael L. Jackson,
Louise E. Kimball,
Jennifer Logue,
Victoria Lyon,
Kira L. Newman,
Monica Zigman Suchsland
Publication year - 2020
Publication title -
science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 12.556
H-Index - 1186
eISSN - 1095-9203
pISSN - 0036-8075
DOI - 10.1126/science.abc0523
Subject(s) - covid-19 , transmission (telecommunications) , betacoronavirus , sars virus , virology , coronavirus infections , state (computer science) , biology , medicine , computer science , telecommunications , outbreak , infectious disease (medical specialty) , disease , pathology , algorithm
After its emergence in Wuhan, China, in late November or early December 2019, the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus rapidly spread globally. Genome sequencing of SARS-CoV-2 allows the reconstruction of its transmission history, although this is contingent on sampling. We analyzed 453 SARS-CoV-2 genomes collected between 20 February and 15 March 2020 from infected patients in Washington state in the United States. We find that most SARS-CoV-2 infections sampled during this time derive from a single introduction in late January or early February 2020, which subsequently spread locally before active community surveillance was implemented.

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