Open AccessMosquito cellular immunity at single-cell resolution
Author(s) -
Gianmarco Raddi,
Ana Beatriz F. Barletta,
Mirjana Efremova,
José L. Ramírez,
Rafael Cantera,
Sarah A. Teichmann,
Carolina BarillasMury,
Oliver Billker
Publication year - 2020
Publication title -
science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 12.556
H-Index - 1186
eISSN - 1095-9203
pISSN - 0036-8075
DOI - 10.1126/science.abc0322
Subject(s) - biology , immune system , aedes aegypti , anopheles gambiae , hemocyte , rna interference , gene silencing , gene , immunity , immunology , virology , population , vector (molecular biology) , rna , malaria , genetics , ecology , recombinant dna , medicine , environmental health , larva
Teasing apart the mosquito immune system Hemocytes are key immune cells of insects, playing a major role in how vector species transmit disease. Raddiet al. collected and sequenced the RNA of more than 8000 individual hemocytes from the disease-carrying mosquitoesAnopheles gambiae andAedes aegypti . These data were then analyzed to determine hemocyte differentiation lineages and population changes in response to noninfected andPlasmodium -infected blood meals. From these data, the researchers identified a new hemocyte type, the megacyte, defined by the transcription of specific marker genes. Gene-silencing experiments implied that the megacyte functions in hemocyte differentiation during immune priming and thus may be involved in the immune response in mosquitoes.Science , this issue p.1128
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