Feasibility of blood testing combined with PET-CT to screen for cancer and guide intervention | Zendy

Anne Marie Len | Zendy; Adam H. Buchanan | Zendy; Isaac Kinde | Zendy; Andrew Warren | Zendy; Ashley Honushefsky | Zendy; Ariella Cohain | Zendy; David H. Ledbetter | Zendy; Fred Sanfilippo | Zendy; Kathleen Sheridan | Zendy; Dillenia Rosica | Zendy; Christian S. Adonizio | Zendy; Hee Jung Hwang | Zendy; Kamel Lahouel | Zendy; Joshua D. Cohen | Zendy; Christopher Douville | Zendy; Aalpen A. Patel | Zendy; Leonardo N. Hagmann | Zendy; David D.K. Rolston | Zendy; Nirav Malani | Zendy; Shibin Zhou | Zendy; Chetan Bettegowda | Zendy; David L. Diehl | Zendy; Bobbi Urban | Zendy; Christopher D. Still | Zendy; Lisa Kann | Zendy; Julie Woods | Zendy; Zachary M. Salvati | Zendy; Joseph Vadakara | Zendy; Rosemary Leeming | Zendy; Prianka Bhattacharya | Zendy; Carroll N. Walter | Zendy; Alex Parker | Zendy; Christoph Lengauer | Zendy; Alison P. Klein | Zendy; Cristian Tomasetti | Zendy; Elliot K. Fishman | Zendy; Ralph H. Hruban | Zendy; Kenneth W. Kinzler | Zendy; Bert Vogelstein | Zendy; Nickolas Papadopoulos | Zendy

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Feasibility of blood testing combined with PET-CT to screen for cancer and guide intervention

Author(s) -

Anne Marie Len,

Adam H. Buchanan,

Isaac Kinde,

Andrew Warren,

Ashley Honushefsky,

Ariella Cohain,

David H. Ledbetter,

Fred Sanfilippo,

Kathleen Sheridan,

Dillenia Rosica,

Christian S. Adonizio,

Hee Jung Hwang,

Kamel Lahouel,

Joshua D. Cohen,

Christopher Douville,

Aalpen A. Patel,

Leonardo N. Hagmann,

David D.K. Rolston,

Nirav Malani,

Shibin Zhou,

Chetan Bettegowda,

David L. Diehl,

Bobbi Urban,

Christopher D. Still,

Lisa Kann,

Julie Woods,

Zachary M. Salvati,

Joseph Vadakara,

Rosemary Leeming,

Prianka Bhattacharya,

Carroll N. Walter,

Alex Parker,

Christoph Lengauer,

Alison P. Klein,

Cristian Tomasetti,

Elliot K. Fishman,

Ralph H. Hruban,

Kenneth W. Kinzler,

Bert Vogelstein,

Nickolas Papadopoulos

Publication year - 2020

Publication title -

science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 12.556

H-Index - 1186

eISSN - 1095-9203

pISSN - 0036-8075

DOI - 10.1126/science.abb9601

Subject(s) - medicine , blood cancer , blood test , positron emission tomography , cancer , test (biology) , disease , nuclear medicine , medical physics , oncology , radiology , surgery , paleontology , biology

A real-time trial of a cancer blood test Cancers diagnosed early are often more responsive to treatment. Blood tests that detect molecular markers of cancer have successfully identified individuals already known to have the disease. Lennonet al. conducted an exploratory study that more closely reflects the way in which such blood tests would be used in the future. They evaluated the feasibility and safety of incorporating a multicancer blood test into the routine clinical care of 10,000 women with no history of cancer. Over a 12-month period, the blood test detected 26 cancers of different types. A combination of the blood test and positron emission tomography–computed tomography (PET-CT) imaging led to surgical removal of nine of these cancers. Use of the blood test did not result in a large number of futile follow-up procedures.Science , this issue p.eabb9601

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