Gene regulatory networks controlling vertebrate retinal regeneration | Zendy

Thanh Hoang | Zendy; Jie Wang | Zendy; Patrick Boyd | Zendy; Fang Wang | Zendy; Clayton P. Santiago | Zendy; Lizhi Jiang | Zendy; Sooyeon Yoo | Zendy; Manuela Lahne | Zendy; Levi Todd | Zendy; Meng Jia | Zendy; Cristian Saez Gonzalez | Zendy; Casey Keuthan | Zendy; Isabella Palazzo | Zendy; Natalie Squires | Zendy; Warren A. Campbell | Zendy; Fatemeh Rajaii | Zendy; Trisha Parayil | Zendy; Vickie Trinh | Zendy; Dong Won Kim | Zendy; Guohua Wang | Zendy; Leah J. Campbell | Zendy; John D. Ash | Zendy; Andy J. Fischer | Zendy; David R. Hyde | Zendy; Jiang Qian | Zendy; Seth Blackshaw | Zendy

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Gene regulatory networks controlling vertebrate retinal regeneration

Author(s) -

Thanh Hoang,

Jie Wang,

Patrick Boyd,

Fang Wang,

Clayton P. Santiago,

Lizhi Jiang,

Sooyeon Yoo,

Manuela Lahne,

Levi Todd,

Meng Jia,

Cristian Saez Gonzalez,

Casey Keuthan,

Isabella Palazzo,

Natalie Squires,

Warren A. Campbell,

Fatemeh Rajaii,

Trisha Parayil,

Vickie Trinh,

Dong Won Kim,

Guohua Wang,

Leah J. Campbell,

John D. Ash,

Andy J. Fischer,

David R. Hyde,

Jiang Qian,

Seth Blackshaw

Publication year - 2020

Publication title -

science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 12.556

H-Index - 1186

eISSN - 1095-9203

pISSN - 0036-8075

DOI - 10.1126/science.abb8598

Subject(s) - muller glia , neurogenesis , biology , zebrafish , retinal regeneration , regeneration (biology) , microbiology and biotechnology , vertebrate , retinal , chromatin , progenitor cell , transcription factor , retina , gene regulatory network , neuroscience , gene , stem cell , gene expression , genetics , biochemistry

Unlocking retinal regeneration in mice Zebrafish can regenerate damaged retinal tissue, but mice cannot. Hoanget al. found that tracking changes in gene expression and chromatin accessibility upon injury revealed clues as to why retinal glial cells in zebrafish could generate new neurons but the same cell type in mice could not. In zebrafish, activated Müller glial cells shift into a proliferative phase, whereas in mice, a genetic network returns the glial cells to quiescence. A few transcription factors enforce quiescence in the mouse, and disruption of these allowed Müller glia to proliferate and generate new neurons after retinal injury.Science , this issue p.eabb8598

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