Tau: Enabler of diverse brain disorders and target of rapidly evolving therapeutic strategies | Zendy

Che-Wei Chang | Zendy; Qiang Shao | Zendy; Lennart Mucke | Zendy

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Tau: Enabler of diverse brain disorders and target of rapidly evolving therapeutic strategies

Author(s) -

Che-Wei Chang,

Qiang Shao,

Lennart Mucke

Publication year - 2021

Publication title -

science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 12.556

H-Index - 1186

eISSN - 1095-9203

pISSN - 0036-8075

DOI - 10.1126/science.abb8255

Subject(s) - neuroscience , drug target , brain disease , disease , drug development , drug , medicine , psychology , pharmacology , pathology

The many faces of tau The protein tau is implicated in several brain disorders, including Alzheimer's disease, suggesting that it could be a target of therapeutics. However, because it is unclear how the pleiotropic roles of tau lead to neural pathology in different brain diseases, drug development remains challenging. Changet al. review the possible mechanisms of tau in brain diseases and possible paths forward to improving research and drug development.Science , this issue p.eabb8255

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