A synthetic synaptic organizer protein restores glutamatergic neuronal circuits | Zendy

K. Suzuki | Zendy; Jonathan Elegheert | Zendy; Inseon Song | Zendy; Hiroyuki Sasakura | Zendy; Oleg Senkov | Zendy; Keiko Matsuda | Zendy; Wataru Kakegawa | Zendy; Amber J. Clayton | Zendy; Veronica T. Chang | Zendy; Maura Ferrer-Ferrer | Zendy; Eriko Miura | Zendy; Rahul Kaushik | Zendy; Masashi Ikeno | Zendy; Yuki Morioka | Zendy; Yuka Takeuchi | Zendy; Tatsuya Shimada | Zendy; Shintaro Otsuka | Zendy; Stoyan Stoyanov | Zendy; Masahiko Watanabe | Zendy; Kosei Takeuchi | Zendy; Alexander Dityatev | Zendy; A.R. Aricescu | Zendy; Michisuke Yuzaki | Zendy

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A synthetic synaptic organizer protein restores glutamatergic neuronal circuits

Author(s) -

K. Suzuki,

Jonathan Elegheert,

Inseon Song,

Hiroyuki Sasakura,

Oleg Senkov,

Keiko Matsuda,

Wataru Kakegawa,

Amber J. Clayton,

Veronica T. Chang,

Maura Ferrer-Ferrer,

Eriko Miura,

Rahul Kaushik,

Masashi Ikeno,

Yuki Morioka,

Yuka Takeuchi,

Tatsuya Shimada,

Shintaro Otsuka,

Stoyan Stoyanov,

Masahiko Watanabe,

Kosei Takeuchi,

Alexander Dityatev,

A.R. Aricescu,

Michisuke Yuzaki

Publication year - 2020

Publication title -

science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 12.556

H-Index - 1186

eISSN - 1095-9203

pISSN - 0036-8075

DOI - 10.1126/science.abb4853

Subject(s) - neuroscience , glutamatergic , excitatory postsynaptic potential , neurotransmission , neuronal circuits , synapse , synaptic pharmacology , biological neural network , biology , synaptic fatigue , inhibitory postsynaptic potential , glutamate receptor , receptor , biochemistry

Synthetic excitatory synaptic organizer The human brain contains trillions of synapses within a vast network of neurons. Synapse remodeling is essential to ensure the efficient reception and integration of external stimuli and to store and retrieve information. Building and remodeling of synapses occurs throughout life under the control of synaptic organizer proteins. Errors in this process can lead to neuropsychiatric or neurological disorders. Suzukiet al. combined structural elements of natural synaptic organizers to develop an artificial version called CPTX, which has different binding properties (see the Perspective by Salinas). CPTX could act as a molecular bridge to reconnect neurons and restore excitatory synaptic function in animal models of cerebellar ataxia, familial Alzheimer's disease, and spinal cord injury. The findings illustrate how structure-guided approaches can help to repair neuronal circuits.Science , this issue p.eabb4853 ; see also p.1052

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