Lineage analysis reveals an endodermal contribution to the vertebrate pituitary | Zendy

Péter Fábián | Zendy; Kuo-Chang Tseng | Zendy; Joanna Smeeton | Zendy; Joseph J. Lancman | Zendy; P. Duc Si Dong | Zendy; Robert Cerny | Zendy; J. Gage Crump | Zendy

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Lineage analysis reveals an endodermal contribution to the vertebrate pituitary

Author(s) -

Péter Fábián,

Kuo-Chang Tseng,

Joanna Smeeton,

Joseph J. Lancman,

P. Duc Si Dong,

Robert Cerny,

J. Gage Crump

Publication year - 2020

Publication title -

science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 12.556

H-Index - 1186

eISSN - 1095-9203

pISSN - 0036-8075

DOI - 10.1126/science.aba4767

Subject(s) - ectoderm , vertebrate , biology , endoderm , pituitary gland , zebrafish , lineage (genetic) , pars intermedia , posterior pituitary , anatomy , embryo , hormone , microbiology and biotechnology , cellular differentiation , endocrinology , embryogenesis , gene , genetics

Origins of the pituitary gland Placodes are specializations of the head ectoderm that are considered the source of many vertebrate novelties, including the nose, lens, ear, and hormone-producing portion of the pituitary. However, the presence of a pituitary-like structure in nonvertebrate chordates, derived instead from the endoderm, had suggested that the pituitary may predate placodes. Fabianet al. performed lineage tracing, time-lapse imaging, and single-cell messenger RNA sequencing to show that both endodermal and ectodermal cells can generate hormone-producing cells of the zebrafish pituitary. These experiments support that the vertebrate pituitary arises through interactions of an ancestral endodermal protopituitary with newly evolved placodal ectoderm.Science , this issue p.463

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