Preventing Engrailed-1 activation in fibroblasts yields wound regeneration without scarring | Zendy

Shamik Mascharak | Zendy; Heather E. desJardins-Park | Zendy; Michael F. Davitt | Zendy; Michelle Griffin | Zendy; Mimi R. Borrelli | Zendy; Alessandra L. Moore | Zendy; Kellen Chen | Zendy; Bryan Duoto | Zendy; Malini Chinta | Zendy; Deshka S. Foster | Zendy; Abra H. Shen | Zendy; Michael Januszyk | Zendy; Sun Hyung Kwon | Zendy; Gerlinde Wernig | Zendy; Derrick C. Wan | Zendy; H. Peter Lorenz | Zendy; Geoffrey C. Gurtner | Zendy; Michael T. Longaker | Zendy

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Preventing Engrailed-1 activation in fibroblasts yields wound regeneration without scarring

Author(s) -

Shamik Mascharak,

Heather E. desJardins-Park,

Michael F. Davitt,

Michelle Griffin,

Mimi R. Borrelli,

Alessandra L. Moore,

Kellen Chen,

Bryan Duoto,

Malini Chinta,

Deshka S. Foster,

Abra H. Shen,

Michael Januszyk,

Sun Hyung Kwon,

Gerlinde Wernig,

Derrick C. Wan,

H. Peter Lorenz,

Geoffrey C. Gurtner,

Michael T. Longaker

Publication year - 2021

Publication title -

science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 12.556

H-Index - 1186

eISSN - 1095-9203

pISSN - 0036-8075

DOI - 10.1126/science.aba2374

Subject(s) - wound healing , microbiology and biotechnology , regeneration (biology) , mechanotransduction , engrailed , fibroblast , knockout mouse , biology , pathology , anatomy , immunology , medicine , in vitro , receptor , gene expression , gene , genetics , homeobox

Regeneration without scarring Wounds in adult mammals typically heal by forming fibrotic scars. Mascharaket al. found that a specific population of skin fibroblasts (Engrailed-1 lineage–negative fibroblasts) activate expression ofEngrailed-1 and turn on profibrotic cellular programs in response to local tissue mechanics in wounds (see the Perspective by Konieczny and Naik). When mechanical signaling was inhibited in these cells (using either genetic deletion or small-molecule inhibition), skin wounds in mice no longer formed scars but instead healed by regeneration, restoring skin with normal hair follicles and glands, extracellular matrix, and mechanical strength.Science , this issue p.eaba2374 ; see also p.346

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