Reconstitution of autophagosome nucleation defines Atg9 vesicles as seeds for membrane formation | Zendy

Justyna SawaMakarska | Zendy; Verena Baumann | Zendy; Nicolas Coudevylle | Zendy; Sören von Bülow | Zendy; Veronika Nogellova | Zendy; Christine Abert | Zendy; Martina Schuschnig | Zendy; Martin Graef | Zendy; Gerhard Hummer | Zendy; Sascha Martens | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Reconstitution of autophagosome nucleation defines Atg9 vesicles as seeds for membrane formation

Author(s) -

Justyna SawaMakarska,

Verena Baumann,

Nicolas Coudevylle,

Sören von Bülow,

Veronika Nogellova,

Christine Abert,

Martina Schuschnig,

Martin Graef,

Gerhard Hummer,

Sascha Martens

Publication year - 2020

Publication title -

science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 12.556

H-Index - 1186

eISSN - 1095-9203

pISSN - 0036-8075

DOI - 10.1126/science.aaz7714

Subject(s) - atg8 , microbiology and biotechnology , autophagy , autophagosome , lipid anchored protein , endoplasmic reticulum , vesicle , chemistry , phosphatidylinositol , biology , membrane , biochemistry , kinase , apoptosis

Reconstituting autophagosome nucleation To stay healthy, our cells must constantly dispose of harmful material. Autophagy, or self-eating, is an important mechanism to ensure the clearance of bulky material. Such material is enwrapped by cellular membranes to form autophagosomes, the contents of which are then degraded. The formation of autophagosomes is a complicated process involving a large number of factors. How they act together in this process is still enigmatic. Sawa-Makarskaet al. recapitulated the initial steps of autophagosome formation using purified autophagy factors from yeast. This approach elucidated some of the organizational principles of the autophagy machinery during the assembly of autophagosomes.Science , this issue p.eaaz7714

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research