Mosquito heat seeking is driven by an ancestral cooling receptor | Zendy

Chloé Greppi | Zendy; Willem J. Laursen | Zendy; Gonzalo Budelli | Zendy; Elaine C. Chang | Zendy; A. Daniels | Zendy; Lena van Giesen | Zendy; Andrea L. Smidler | Zendy; Flaminia Catteruccia | Zendy; Paul Garrity | Zendy

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Mosquito heat seeking is driven by an ancestral cooling receptor

Author(s) -

Chloé Greppi,

Willem J. Laursen,

Gonzalo Budelli,

Elaine C. Chang,

A. Daniels,

Lena van Giesen,

Andrea L. Smidler,

Flaminia Catteruccia,

Paul Garrity

Publication year - 2020

Publication title -

science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 12.556

H-Index - 1186

eISSN - 1095-9203

pISSN - 0036-8075

DOI - 10.1126/science.aay9847

Subject(s) - biology , ionotropic effect , malaria , receptor , ecology , key (lock) , vector (molecular biology) , zoology , mediator , evolutionary biology , microbiology and biotechnology , genetics , immunology , gene , recombinant dna , nmda receptor

Heat seeking is cool Mosquitoes seek hosts using several cues, one of which is body heat. Greppiet al. hypothesized that cooling-activated receptors could be used for locating mammalian hosts if they were rewired downstream for repulsion responses (see the Perspective by Lazzari). A gene family conserved in insects and known to be responsible for sensing changes in temperature in fruit flies was the starting point. Genome-wide analyses and labeled CRISPR-Cas9 mutants allowed visualization of the receptor in neurons ofAnopheles gambiae mosquitoes' antennae and assessment of adult female mosquitoes with a disrupted copy of the receptor. This ancestral insect temperature regulatory system has been repurposed for host-finding by malaria mosquitoes.Science , this issue p.681 ; see also p.628

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