Genetics of schizophrenia in the South African Xhosa | Zendy

Süleyman Gülsüner | Zendy; Dan J. Stein | Zendy; Ezra Susser | Zendy; Goodman Sibeko | Zendy; Adele Pretorius | Zendy; Tom Walsh | Zendy; Lerato Majara | Zendy; Michael M. Mndini | Zendy; Sibonile G. Mqulwana | Zendy; Odwa A. Ntola | Zendy; Silvia Casadei | Zendy; Linda Ngqengelele | Zendy; Viktoriya Korchina | Zendy; Celia van der Merwe | Zendy; Megan Malan | Zendy; Kim Fader | Zendy; M. Feng | Zendy; Emily A. Willoughby | Zendy; Donna M. Muzny | Zendy; Adam Baldinger | Zendy; Howard Andrews | Zendy; Ruben C. Gur | Zendy; Richard A. Gibbs | Zendy; Z. Zingela | Zendy; Mohammed Nagdee | Zendy; Raj Ramesar | Zendy; MaryClaire King | Zendy; Jon McClellan | Zendy

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Genetics of schizophrenia in the South African Xhosa

Author(s) -

Süleyman Gülsüner,

Dan J. Stein,

Ezra Susser,

Goodman Sibeko,

Adele Pretorius,

Tom Walsh,

Lerato Majara,

Michael M. Mndini,

Sibonile G. Mqulwana,

Odwa A. Ntola,

Silvia Casadei,

Linda Ngqengelele,

Viktoriya Korchina,

Celia van der Merwe,

Megan Malan,

Kim Fader,

M. Feng,

Emily A. Willoughby,

Donna M. Muzny,

Adam Baldinger,

Howard Andrews,

Ruben C. Gur,

Richard A. Gibbs,

Z. Zingela,

Mohammed Nagdee,

Raj Ramesar,

MaryClaire King,

Jon McClellan

Publication year - 2020

Publication title -

science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 12.556

H-Index - 1186

eISSN - 1095-9203

pISSN - 0036-8075

DOI - 10.1126/science.aay8833

Subject(s) - xhosa , schizophrenia (object oriented programming) , biology , genetics , population , disease , psychiatric genetics , psychiatry , neuroscience , psychology , medicine , environmental health , pathology , philosophy , linguistics

African schizophrenia genetic variants The genetics of schizophrenia have predominately been studied in populations of European and Asian descent. However, studies in Africans, who host the greatest degree of human genetic diversity, have lagged. Examining the exomes of more than 1800 Xhosa individuals from South Africa, about half of which have been diagnosed with schizophrenia, Gulsuneret al. identified both rare and common genetic variants associated with the disease. They found that the genetic architecture of schizophrenia in Africans generally reflects that of Europeans but that the greater genetic variation in Africa provides more power to detect relationships of genes to phenotypes.Science , this issue p.569

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