Transcription factor AP2 controls cnidarian germ cell induction | Zendy

Timothy Q. DuBuc | Zendy; Christine E. Schnitzler | Zendy; Eleni Chrysostomou | Zendy; Emma T McMahon | Zendy; Febrimarsa Febrimarsa | Zendy; James M. Gahan | Zendy; Tara Buggie | Zendy; Sebastian G. Gornik | Zendy; Shirley Hanley | Zendy; Sofia N. Barreira | Zendy; Paul Gonzalez | Zendy; Andreas D. Baxevanis | Zendy; Uri Frank | Zendy

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Transcription factor AP2 controls cnidarian germ cell induction

Author(s) -

Timothy Q. DuBuc,

Christine E. Schnitzler,

Eleni Chrysostomou,

Emma T McMahon,

Febrimarsa Febrimarsa,

James M. Gahan,

Tara Buggie,

Sebastian G. Gornik,

Shirley Hanley,

Sofia N. Barreira,

Paul Gonzalez,

Andreas D. Baxevanis,

Uri Frank

Publication year - 2020

Publication title -

science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 12.556

H-Index - 1186

eISSN - 1095-9203

pISSN - 0036-8075

DOI - 10.1126/science.aay6782

Subject(s) - transcription factor , germ , germ cell , biology , microbiology and biotechnology , genetics , gene

Conserved gene specifies germ cell Germ cells are the exclusive progenitors of gametes. In most studied animals, including humans, germ cells are produced only once during embryogenesis and are not replenished in adult life. DuBucet al. studied germ cell induction in the clonal cnidarianHydractinia symbiolongicarpus , an animal that forms germ cells continuously in adult life from stem cells that also generate somatic cells. A single transcription factor is capable of converting the animal's adult stem cells to germ cells. A similar gene also controls germ cell induction in mammalian embryos, but its action there is limited to a single event in early embryogenesis.Science , this issue p.757

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