Deregulation of ribosomal protein expression and translation promotes breast cancer metastasis | Zendy

Richard Y. Ebright | Zendy; Sooncheol Lee | Zendy; Ben S. Wittner | Zendy; Kira Niederhoffer | Zendy; Benjamin Nicholson | Zendy; Aditya Bardia | Zendy; Samuel S. Truesdell | Zendy; Devon F. Wiley | Zendy; Benjamin Wesley | Zendy; Selena S. Li | Zendy; Andy Mai | Zendy; Nicola Aceto | Zendy; Nicole Vincent-Jordan | Zendy; Annamária Szabolcs | Zendy; Brian Chirn | Zendy; Johannes Kreuzer | Zendy; Valentine Comaills | Zendy; Mark Kalinich | Zendy; Wilhelm Haas | Zendy; David T. Ting | Zendy; Mehmet Toner | Zendy; Shobha Vasudevan | Zendy; Daniel A. Haber | Zendy; Shyamala Maheswaran | Zendy; Douglas S. Micalizzi | Zendy

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Deregulation of ribosomal protein expression and translation promotes breast cancer metastasis

Author(s) -

Richard Y. Ebright,

Sooncheol Lee,

Ben S. Wittner,

Kira Niederhoffer,

Benjamin Nicholson,

Aditya Bardia,

Samuel S. Truesdell,

Devon F. Wiley,

Benjamin Wesley,

Selena S. Li,

Andy Mai,

Nicola Aceto,

Nicole Vincent-Jordan,

Annamária Szabolcs,

Brian Chirn,

Johannes Kreuzer,

Valentine Comaills,

Mark Kalinich,

Wilhelm Haas,

David T. Ting,

Mehmet Toner,

Shobha Vasudevan,

Daniel A. Haber,

Shyamala Maheswaran,

Douglas S. Micalizzi

Publication year - 2020

Publication title -

science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 12.556

H-Index - 1186

eISSN - 1095-9203

pISSN - 0036-8075

DOI - 10.1126/science.aay0939

Subject(s) - metastasis , translation (biology) , metastatic breast cancer , breast cancer , cancer research , circulating tumor cell , cancer , biology , ribosomal protein , medicine , oncology , ribosome , messenger rna , rna , genetics , gene

Metastasis: A matter of translation? Solid tumors shed a small number of cancer cells into the bloodstream, some of which are believed to contribute to metastasis. The molecular features that confer these circulating tumor cells (CTCs) with metastatic potential are poorly understood. Ebrightet al. studied CTCs from breast cancer patients and found that cells with increased expression levels of certain ribosomal proteins and regulators of translation had greater metastatic capacity in a mouse model (see the Perspective by Ma and Jeffrey). Consistent with this finding, patients with higher levels of this subset of CTCs tended to have a poorer prognosis.Science , this issue p.1468 ; see also p.1424

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