Identification of a T follicular helper cell subset that drives anaphylactic IgE | Zendy

Uthaman Gowthaman | Zendy; Jennifer Chen | Zendy; Biyan Zhang | Zendy; William F. Flynn | Zendy; Yisi Lu | Zendy; Wenzhi Song | Zendy; Julie Joseph | Zendy; Jake A. Gertie | Zendy; Lan Xu | Zendy; Magalie A. Collet | Zendy; Jessica Grassmann | Zendy; Tregony Simoneau | Zendy; David Chiang | Zendy; M. Cecilia Berin | Zendy; Joseph Craft | Zendy; Jason S. Weinstein | Zendy; Adam Williams | Zendy; Stephanie C. Eisenbarth | Zendy

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Identification of a T follicular helper cell subset that drives anaphylactic IgE

Author(s) -

Uthaman Gowthaman,

Jennifer Chen,

Biyan Zhang,

William F. Flynn,

Yisi Lu,

Wenzhi Song,

Julie Joseph,

Jake A. Gertie,

Lan Xu,

Magalie A. Collet,

Jessica Grassmann,

Tregony Simoneau,

David Chiang,

M. Cecilia Berin,

Joseph Craft,

Jason S. Weinstein,

Adam Williams,

Stephanie C. Eisenbarth

Publication year - 2019

Publication title -

science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 12.556

H-Index - 1186

eISSN - 1095-9203

pISSN - 0036-8075

DOI - 10.1126/science.aaw6433

Subject(s) - immunoglobulin e , immunology , cd23 , antibody , population , allergen , anaphylaxis , interleukin 4 , bcl6 , gata3 , isotype , b cell , biology , allergy , cytokine , monoclonal antibody , medicine , transcription factor , germinal center , gene , biochemistry , environmental health

Thirteen is the charm in anaphylaxis Immunoglobulin E (IgE) is a type of antibody associated with allergies and response to parasites such as worms. When high-affinity, allergen-specific IgE binds its target, it can cross-link receptors on mast cells that induce anaphylaxis. It remains unclear, however, how B cells are instructed to generate high-affinity IgE. Gowthamanet al. discovered a subset of T follicular helper cells (TFH 13) that direct B cells to do just that. TFH 13 cells are induced by allergens but not during parasite infection. Transgenic mice lacking these cells show impaired production of high-affinity, anaphylactic IgE. TFH 13 cells, which are elevated in patients with food and aeroallergies, may be targeted in future antianaphylaxis therapies.Science , this issue p.eaaw6433

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