Blood factors transfer beneficial effects of exercise on neurogenesis and cognition to the aged brain | Zendy

Alana Horowitz | Zendy; Xuelai Fan | Zendy; Gregor Bieri | Zendy; Lucas K. Smith | Zendy; Cesar Sanchez-Diaz | Zendy; Adam B. Schroer | Zendy; Géraldine Gontier | Zendy; Kaitlin B. Casaletto | Zendy; Joel H. Kramer | Zendy; Katherine Williams | Zendy; Saul Villeda | Zendy

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Blood factors transfer beneficial effects of exercise on neurogenesis and cognition to the aged brain

Author(s) -

Alana Horowitz,

Xuelai Fan,

Gregor Bieri,

Lucas K. Smith,

Cesar Sanchez-Diaz,

Adam B. Schroer,

Géraldine Gontier,

Kaitlin B. Casaletto,

Joel H. Kramer,

Katherine Williams,

Saul Villeda

Publication year - 2020

Publication title -

science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 12.556

H-Index - 1186

eISSN - 1095-9203

pISSN - 0036-8075

DOI - 10.1126/science.aaw2622

Subject(s) - neurogenesis , cognition , treadmill , physical exercise , psychology , plasma levels , endocrinology , medicine , neuroscience

Plasma transfers exercise benefit in mice Exercise has a broad range of beneficial healthful effects. Horowitzet al. tested whether the beneficial effects of exercise on neurogenesis in the brain and improved cognition in aged mice could be transferred in plasma (blood without its cellular components) from one mouse to another (see the Perspective by Ansere and Freeman). Indeed, aged mice that received plasma from young or old mice that had exercised showed beneficial effects in their brains without hitting the treadmill. The authors identified glycosylphosphatidylinositol-specific phospholipase D1 as a factor in plasma that might, in part, mediate this favorable effect.Science , this issue p.167 ; see also p.144

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