Vertebrate diapause preserves organisms long term through Polycomb complex members | Zendy

ChiKuo Hu | Zendy; Wei Wang | Zendy; Julie Brind’Amour | Zendy; Param Priya Singh | Zendy; G. Reeves | Zendy; Matthew C. Lorincz | Zendy; Alejandro Sánchez Alvarado | Zendy; Anne Brunet | Zendy

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Vertebrate diapause preserves organisms long term through Polycomb complex members

Author(s) -

ChiKuo Hu,

Wei Wang,

Julie Brind’Amour,

Param Priya Singh,

G. Reeves,

Matthew C. Lorincz,

Alejandro Sánchez Alvarado,

Anne Brunet

Publication year - 2020

Publication title -

science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 12.556

H-Index - 1186

eISSN - 1095-9203

pISSN - 0036-8075

DOI - 10.1126/science.aaw2601

Subject(s) - diapause , biology , chromatin , vertebrate , adaptation (eye) , killifish , gene , evolutionary biology , microbiology and biotechnology , genetics , ecology , neuroscience , fishery , larva , fish <actinopterygii>

Putting vertebrate development on hold Suspended animation is an often-used device in science fiction, but it also exists in several forms in nature: hibernation, torpor, and diapause. Huet al. studied diapause in the African turquoise killifish, a vertebrate model system (see the Perspective by Van Gilst). They found that diapause protects a complex living organism without trade-offs for future growth, fertility, and even life span. Diapause is actively regulated, with a dynamic switch to specific Polycomb complex members. One Polycomb member, CBX7, is critical for the regulation of organ genes and is involved in muscle preservation and diapause maintenance. This work illuminates the mechanisms that underlie suspended life.Science , this issue p.870 ; see also p.851

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