Single-cell genomics identifies cell type–specific molecular changes in autism | Zendy

Dmitry Velmeshev | Zendy; Lucas Schirmer | Zendy; Diane Jung | Zendy; Maximilian Haeussler | Zendy; Yonatan Perez | Zendy; Simone Mayer | Zendy; Aparna Bhaduri | Zendy; Nitasha Goyal | Zendy; David H. Rowitch | Zendy; Arnold R. Kriegstein | Zendy

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Single-cell genomics identifies cell type–specific molecular changes in autism

Author(s) -

Dmitry Velmeshev,

Lucas Schirmer,

Diane Jung,

Maximilian Haeussler,

Yonatan Perez,

Simone Mayer,

Aparna Bhaduri,

Nitasha Goyal,

David H. Rowitch,

Arnold R. Kriegstein

Publication year - 2019

Publication title -

science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 12.556

H-Index - 1186

eISSN - 1095-9203

pISSN - 0036-8075

DOI - 10.1126/science.aav8130

Subject(s) - autism , neocortex , transcriptome , biology , neuroscience , genomics , cell type , microglia , neural cell , neural stem cell , cell , gene , genetics , genome , gene expression , psychology , stem cell , psychiatry , immunology , inflammation

Brain cell transcriptomes in autism Autism manifests in many ways. Despite that diversity, the disorder seems to affect specific cellular pathways, including those observed in the neocortex of patients' brains. Velmeshevet al. analyzed the transcriptomes of single brain cells, including neurons and glia, from patients with autism. Single-nucleus RNA sequencing analysis suggested that affected pathways regulate synapse function as well as neural outgrowth and migration. Furthermore, in patient samples, specific sets of genes enriched in upper-layer projection neurons and microglia correlated with clinical severity.Science , this issue p.685

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