Sphingosine 1-phosphate: Lipid signaling in pathology and therapy | Zendy

Andréane Cartier | Zendy; Timothy Hla | Zendy

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Sphingosine 1-phosphate: Lipid signaling in pathology and therapy

Author(s) -

Andréane Cartier,

Timothy Hla

Publication year - 2019

Publication title -

science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 12.556

H-Index - 1186

eISSN - 1095-9203

pISSN - 0036-8075

DOI - 10.1126/science.aar5551

Subject(s) - sphingosine 1 phosphate , sphingosine , mediator , lipid signaling , neuroscience , signal transduction , lipid metabolism , disease , drug development , multiple sclerosis , medicine , microbiology and biotechnology , fibrosis , sphingolipid , bioinformatics , biology , immunology , drug , receptor , pharmacology , pathology , inflammation

Mediating systemic health Sphingosine 1-phosphate (S1P) is an important circulating lipid mediator that is derived from the metabolism of cell membranes. Its diverse homeostatic roles, particularly in immunology and vascular biology, can go awry in numerous diseases, including multiple sclerosis, cardiovascular diseases, and fibrosis. The centrality of S1P signaling has led to the development of several drugs, including two approved for treatment of multiple sclerosis. In a Review, Cartier and Hla discuss the current understanding of how one mediator can carry out so many signaling roles in different tissues, how these become dysregulated in disease, and efforts in drug development to target S1P signaling. Science , this issue p.eaar5551

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