Clonal hematopoiesis in human aging and disease | Zendy

Siddhartha Jaiswal | Zendy; Benjamin L. Ebert | Zendy

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Clonal hematopoiesis in human aging and disease

Author(s) -

Siddhartha Jaiswal,

Benjamin L. Ebert

Publication year - 2019

Publication title -

science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 12.556

H-Index - 1186

eISSN - 1095-9203

pISSN - 0036-8075

DOI - 10.1126/science.aan4673

Subject(s) - haematopoiesis , disease , biology , genetics , medicine , stem cell

Cryptic signs of aging in our blood Time is not a friend to our DNA. Aging is associated with an accumulation of somatic mutations in normal dividing cells, including the hematopoietic stem cells (HSCs) that give rise to all blood cells. Certain mutations in HSCs confer a fitness advantage that results in clonal expansions of mutant blood cells that sometimes—but not always—forecast the development of cancer and other age-related diseases. Jaiswal and Ebert review this process of “clonal hematopoiesis,” including the mechanisms by which it arises and the current state of knowledge regarding its effects on human health. Science , this issue p.eaan4673

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