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Blueprint for a macromolecular machine Nuclear pore complexes (NPCs) consist of around 1000 protein subunits, are embedded in the membrane that surrounds the nucleus, and regulate transport between the nucleus and the cytoplasm. Although the overall shape of NPCs is known, the details of this macromolecular complex have been obscure. Now, Linet al. have reconstituted the pore components, determined the interactions between them, and fitted them into a tomographic reconstruction. Kosinskiet al. have provided an architectural map of the inner ring of the pore.Science , this issue pp.10.1126/science.aaf1015 and363

Molecular architecture of the inner ring scaffold of the human nuclear pore complex