Molecular architecture of the inner ring scaffold of the human nuclear pore complex | Zendy

Jan Kosiński | Zendy; Shyamal Mosalaganti | Zendy; Alexander von Appen | Zendy; Roman Teimer | Zendy; Amanda L. DiGuilio | Zendy; William Wan | Zendy; Khanh Huy Bui | Zendy; Wim J. H. Hagen | Zendy; John A. G. Briggs | Zendy; Joseph S. Glavy | Zendy; Ed Hurt | Zendy; Martin Beck | Zendy

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Molecular architecture of the inner ring scaffold of the human nuclear pore complex

Author(s) -

Jan Kosiński,

Shyamal Mosalaganti,

Alexander von Appen,

Roman Teimer,

Amanda L. DiGuilio,

William Wan,

Khanh Huy Bui,

Wim J. H. Hagen,

John A. G. Briggs,

Joseph S. Glavy,

Ed Hurt,

Martin Beck

Publication year - 2016

Publication title -

science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 12.556

H-Index - 1186

eISSN - 1095-9203

pISSN - 0036-8075

DOI - 10.1126/science.aaf0643

Subject(s) - nuclear pore , nucleus , cytoplasm , macromolecule , ring (chemistry) , inner membrane , biophysics , nucleoporin , chemistry , crystallography , materials science , cell nucleus , membrane , nuclear transport , microbiology and biotechnology , biology , biochemistry , organic chemistry

Blueprint for a macromolecular machine Nuclear pore complexes (NPCs) consist of around 1000 protein subunits, are embedded in the membrane that surrounds the nucleus, and regulate transport between the nucleus and the cytoplasm. Although the overall shape of NPCs is known, the details of this macromolecular complex have been obscure. Now, Linet al. have reconstituted the pore components, determined the interactions between them, and fitted them into a tomographic reconstruction. Kosinskiet al. have provided an architectural map of the inner ring of the pore.Science , this issue pp.10.1126/science.aaf1015 and363

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