Translational control by 5′-untranslated regions of eukaryotic mRNAs | Zendy

Alan G. Hinnebusch | Zendy; Ivaylo P. Ivanov | Zendy; Nahum Sonenberg | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Translational control by 5′-untranslated regions of eukaryotic mRNAs

Author(s) -

Alan G. Hinnebusch,

Ivaylo P. Ivanov,

Nahum Sonenberg

Publication year - 2016

Publication title -

science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 12.556

H-Index - 1186

eISSN - 1095-9203

pISSN - 0036-8075

DOI - 10.1126/science.aad9868

Subject(s) - five prime untranslated region , eukaryotic initiation factor , start codon , internal ribosome entry site , biology , initiation factor , translation (biology) , untranslated region , eukaryotic translation , messenger rna , translational regulation , eif4a1 , genetics , eukaryotic translation initiation factor 4 gamma , ribosomal binding site , three prime untranslated region , microbiology and biotechnology , ribosome , rna , gene

The eukaryotic 5' untranslated region (UTR) is critical for ribosome recruitment to the messenger RNA (mRNA) and start codon choice and plays a major role in the control of translation efficiency and shaping the cellular proteome. The ribosomal initiation complex is assembled on the mRNA via a cap-dependent or cap-independent mechanism. We describe various mechanisms controlling ribosome scanning and initiation codon selection by 5' upstream open reading frames, translation initiation factors, and primary and secondary structures of the 5'UTR, including particular sequence motifs. We also discuss translational control via phosphorylation of eukaryotic initiation factor 2, which is implicated in learning and memory, neurodegenerative diseases, and cancer.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research