CNS Synaptogenesis Promoted by Glia-Derived Cholesterol | Zendy

Daniela H. Mauch | Zendy; Karl Nägler | Zendy; Stefan Schumacher | Zendy; Christian Göritz | Zendy; Eva-Christina Müller | Zendy; Albrecht Otto | Zendy; Frank W. Pfrieger | Zendy

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CNS Synaptogenesis Promoted by Glia-Derived Cholesterol

Author(s) -

Daniela H. Mauch,

Karl Nägler,

Stefan Schumacher,

Christian Göritz,

Eva-Christina Müller,

Albrecht Otto,

Frank W. Pfrieger

Publication year - 2001

Publication title -

science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 12.556

H-Index - 1186

eISSN - 1095-9203

pISSN - 0036-8075

DOI - 10.1126/science.294.5545.1354

Subject(s) - synaptogenesis , biology , neuroscience , central nervous system , cholesterol , neuroglia , apolipoprotein e , synapse , homeostasis , microbiology and biotechnology , endocrinology , medicine , disease

The molecular mechanisms controlling synaptogenesis in the central nervous system (CNS) are poorly understood. Previous reports showed that a glia-derived factor strongly promotes synapse development in cultures of purified CNS neurons. Here, we identify this factor as cholesterol complexed to apolipoprotein E-containing lipoproteins. CNS neurons produce enough cholesterol to survive and grow, but the formation of numerous mature synapses demands additional amounts that must be provided by glia. Thus, the availability of cholesterol appears to limit synapse development. This may explain the delayed onset of CNS synaptogenesis after glia differentiation and neurobehavioral manifestations of defects in cholesterol or lipoprotein homeostasis.

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