Open AccessTargeting OXPHOS de novo purine synthesis as the nexus of FLT3 inhibitor–mediated synergistic antileukemic actions
Author(s) -
Pu Zhang,
Lindsey T. Brinton,
Mehdi Gharghabi,
Steven Sher,
Katie Williams,
Matthew Can,
Janek S. Walker,
Daniel Canfield,
Larry Beaver,
Casey B. Cempre,
Hannah Phillips,
Xuyong Chen,
Pearlly S. Yan,
Amy Lehman,
Peggy Scherle,
Min Wang,
Kris Vaddi,
Robert A. Baiocchi,
Ruoning Wang,
Deepa Sampath,
Lapo Alinari,
James S. Blachly,
Rosa Lapalombella
Publication year - 2022
Publication title -
science advances
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.928
H-Index - 146
ISSN - 2375-2548
DOI - 10.1126/sciadv.abp9005
Subject(s) - glycolysis , oxidative phosphorylation , purine , myeloid leukemia , biochemistry , biology , cancer research , chemistry , microbiology and biotechnology , enzyme
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