Open AccessNeurons burdened by DNA double-strand breaks incite microglia activation through antiviral-like signaling in neurodegeneration
Author(s) -
Gwyneth Welch,
Carles A. Boix,
Eloi Schmauch,
José Dávila-Velderrain,
Matheus B. Victor,
Vishnu Dileep,
P. Lorenzo Bozzelli,
Qiao Su,
Jemmie Cheng,
Audrey Lee,
Noelle Leary,
Andreas R. Pfenning,
Manolis Kellis,
LiHuei Tsai
Publication year - 2022
Publication title -
science advances
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.928
H-Index - 146
ISSN - 2375-2548
DOI - 10.1126/sciadv.abo4662
Subject(s) - neurodegeneration , microglia , neuroinflammation , neuroscience , biology , microbiology and biotechnology , dna damage , immune system , neuron , transcriptome , senescence , inflammation , dna , immunology , medicine , disease , gene , gene expression , pathology , genetics
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