Open AccessATP-competitive inhibitors modulate the substrate binding cooperativity of a kinase by altering its conformational entropy
Author(s) -
Cristina Olivieri,
Geoffrey Li,
Yingjie Wang,
Manu Veliparambil Subrahmanian,
Caitlin Walker,
Jonggul Kim,
Carlo Camilloni,
Alfonso De Simone,
Michele Vendruscolo,
David Bernlohr,
Susan S. Taylor,
Gianluigi Veglia
Publication year - 2022
Publication title -
science advances
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.928
H-Index - 146
ISSN - 2375-2548
DOI - 10.1126/sciadv.abo0696
Subject(s) - allosteric regulation , cooperativity , cooperative binding , kinase , binding site , allosteric enzyme , chemistry , plasma protein binding , biophysics , biochemistry , phosphorylation , enzyme , protein kinase a , entropy (arrow of time) , microbiology and biotechnology , biology , physics , quantum mechanics
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