Open AccessATP-competitive inhibitors modulate the substrate binding cooperativity of a kinase by altering its conformational entropy
Author(s) -
Cristina Olivieri,
Geoffrey C. Li,
Yingjie Wang,
Manu Veliparambil Subrahmanian,
Caitlin Walker,
Jonggul Kim,
Carlo Camilloni,
Alfonso De Simone,
Michele Vendruscolo,
David A. Bernlohr,
Susan S. Taylor,
Gianluigi Veglia
Publication year - 2022
Publication title -
science advances
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.928
H-Index - 146
ISSN - 2375-2548
DOI - 10.1126/sciadv.abo0696
Subject(s) - allosteric regulation , cooperativity , cooperative binding , kinase , binding site , allosteric enzyme , chemistry , plasma protein binding , biophysics , biochemistry , phosphorylation , enzyme , protein kinase a , entropy (arrow of time) , microbiology and biotechnology , biology , physics , quantum mechanics