Open AccessGenome-wide CRISPR screens using isogenic cells reveal vulnerabilities conferred by loss of tumor suppressors
Author(s) -
Xu Feng,
Mengfan Tang,
Merve Dede,
Dan Su,
Guangsheng Pei,
Dadi Jiang,
Chao Wang,
Zhen Chen,
Mi Li,
Litong Nie,
Yun Xiong,
Siting Li,
Jeong-Min Park,
Huimin Zhang,
Min Huang,
Klaudia Szymonowicz,
Zhongming Zhao,
Traver Hart,
Junjie Chen
Publication year - 2022
Publication title -
science advances
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.928
H-Index - 146
ISSN - 2375-2548
DOI - 10.1126/sciadv.abm6638
Subject(s) - suppressor , crispr , genome , gene , biology , loss function , tumor suppressor gene , computational biology , function (biology) , genetics , synthetic lethality , cancer , phenotype , dna repair , carcinogenesis
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