Open AccessPatched 1 regulates Smoothened by controlling sterol binding to its extracellular cysteine-rich domain
Author(s) -
Maia Kinnebrew,
Rachel E. Woolley,
T. Bertie Ansell,
Eamon F.X. Byrne,
Sara Frigui,
Giovanni Luchetti,
Ria Sircar,
Sigrid Nachtergaele,
Laurel MydockMcGrane,
Kathiresan Krishnan,
Simon Newstead,
Mark S.P. Sansom,
Douglas F. Covey,
Christian Siebold,
Rajat Rohatgi
Publication year - 2022
Publication title -
science advances
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.928
H-Index - 146
ISSN - 2375-2548
DOI - 10.1126/sciadv.abm5563
Subject(s) - smoothened , allosteric regulation , patched , sonic hedgehog , microbiology and biotechnology , chemistry , hedgehog signaling pathway , hedgehog , cysteine , biochemistry , biology , signal transduction , receptor , enzyme
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