Open AccessTREM-2 is a sensor and activator of T cell response in SARS-CoV-2 infection
Author(s) -
Yongjian Wu,
Manni Wang,
Huan Yin,
Siqi Ming,
Xingyu Li,
Guanmin Jiang,
Ye Liu,
PeiHui Wang,
Guangde Zhou,
Lei Liu,
Sitang Gong,
Haibo Zhou,
Hong Shan,
Xi Huang
Publication year - 2021
Publication title -
science advances
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.928
H-Index - 146
ISSN - 2375-2548
DOI - 10.1126/sciadv.abi6802
Subject(s) - interferon , biology , stat1 , coronavirus , virology , immunology , t cell , immune system , medicine , covid-19 , disease , infectious disease (medical specialty) , pathology
TREM-2 recognizes SARS-CoV-2 membrane protein and activates CD3ζ/ZAP70/STAT1 signal pathway to induce antiviral TH 1 response.