Open AccessCancer-associated MSC drive tumor immune exclusion and resistance to immunotherapy, which can be overcome by Hedgehog inhibition
Author(s) -
Sandra Cascio,
Chelsea Chandler,
Linan Zhang,
Sarah Sinno,
Bingsi Gao,
Sayali Onkar,
Tullia C. Bruno,
Dario A.A. Vignali,
Haider Mahdi,
Hatice U. Osmanbeyoglu,
Anda Vlad,
Lan Coffman,
Ronald J. Buckanovich
Publication year - 2021
Publication title -
science advances
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.928
H-Index - 146
ISSN - 2375-2548
DOI - 10.1126/sciadv.abi5790
Subject(s) - immune system , immunotherapy , cancer , cancer immunotherapy , cancer research , hedgehog , immunology , biology , medicine , microbiology and biotechnology , signal transduction
HHi reverses the CA-MSC driven tumor immune cell exclusion restoring the response to ICI.
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