G-CSF secreted by mutant IDH1 glioma stem cells abolishes myeloid cell immunosuppression and enhances the efficacy of immunotherapy | Zendy

Mahmoud S. Alghamri | Zendy; Brandon L. McClellan | Zendy; Ruthvik Avvari | Zendy; Rohit Thalla | Zendy; Stephen V. Carney | Zendy; Carson S. Hartlage | Zendy; Santiago Haase | Zendy; Maria Ventosa | Zendy; Ayman Taher | Zendy; Neha Kamran | Zendy; Li Zhang | Zendy; Syed Mohd Faisal | Zendy; Felipe J. Núñez | Zendy; María Belén Garcia-Fabiani | Zendy; Wajd N. AlHolou | Zendy; Daniel A. Orringer | Zendy; Shawn L. HerveyJumper | Zendy; Jason Heth | Zendy; Parag G. Patil | Zendy; Karen Eddy | Zendy; Sofía D. Merajver | Zendy; Peter Ulintz | Zendy; Joshua D. Welch | Zendy; Chao Gao | Zendy; Jialin Liu | Zendy; Gabriel Núñez | Zendy; Dolores Hambardzumyan | Zendy; Pedro R. Löwenstein | Zendy; María G. Castro | Zendy

Open Access

G-CSF secreted by mutant IDH1 glioma stem cells abolishes myeloid cell immunosuppression and enhances the efficacy of immunotherapy

Author(s) -

Mahmoud S. Alghamri,

Brandon L. McClellan,

Ruthvik Avvari,

Rohit Thalla,

Stephen V. Carney,

Carson S. Hartlage,

Santiago Haase,

Maria Ventosa,

Ayman Taher,

Neha Kamran,

Li Zhang,

Syed Mohd Faisal,

Felipe J. Núñez,

María Belén Garcia-Fabiani,

Wajd N. AlHolou,

Daniel A. Orringer,

Shawn L. HerveyJumper,

Jason Heth,

Parag G. Patil,

Karen Eddy,

Sofía D. Merajver,

Peter Ulintz,

Joshua D. Welch,

Chao Gao,

Jialin Liu,

Gabriel Núñez,

Dolores Hambardzumyan,

Pedro R. Löwenstein,

María G. Castro

Publication year - 2021

Publication title -

science advances

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.928

H-Index - 146

ISSN - 2375-2548

DOI - 10.1126/sciadv.abh3243

Subject(s) - myeloid , glioma , cancer research , reprogramming , biology , granulopoiesis , tumor microenvironment , myelopoiesis , immune system , bone marrow , stem cell , immunology , progenitor cell , microbiology and biotechnology , cell , genetics

MutantIDH1 gliomas are infiltrated by nonsuppressive immature myeloid cells, resulting in enhanced response to immunotherapy.

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