Postnatal immune activation causes social deficits in a mouse model of tuberous sclerosis: Role of microglia and clinical implications | Zendy

Manuel F. LópezAranda | Zendy; Ishanu Chattopadhyay | Zendy; Gayle M. Boxx | Zendy; Elizabeth Fraley | Zendy; Tawnie K. Silva | Zendy; Miou Zhou | Zendy; Miranda Phan | Zendy; Isaiah Herrera | Zendy; Sunrae E. Taloma | Zendy; Rochelle Mandanas | Zendy; Karen Bach | Zendy; Michael J. Gandal | Zendy; Daniel H. Geschwind | Zendy; Genhong Cheng | Zendy; Andrey Rzhetsky | Zendy; Stephanie A. White | Zendy; Alcino J. Silva | Zendy

Open Access

Postnatal immune activation causes social deficits in a mouse model of tuberous sclerosis: Role of microglia and clinical implications

Author(s) -

Manuel F. LópezAranda,

Ishanu Chattopadhyay,

Gayle M. Boxx,

Elizabeth Fraley,

Tawnie K. Silva,

Miou Zhou,

Miranda Phan,

Isaiah Herrera,

Sunrae E. Taloma,

Rochelle Mandanas,

Karen Bach,

Michael J. Gandal,

Daniel H. Geschwind,

Genhong Cheng,

Andrey Rzhetsky,

Stephanie A. White,

Alcino J. Silva

Publication year - 2021

Publication title -

science advances

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.928

H-Index - 146

ISSN - 2375-2548

DOI - 10.1126/sciadv.abf2073

Subject(s) - tuberous sclerosis , microglia , immune system , autism , autism spectrum disorder , tsc2 , neurodevelopmental disorder , neuroscience , multiple sclerosis , tsc1 , immunology , medicine , psychology , biology , signal transduction , psychiatry , genetics , inflammation , pi3k/akt/mtor pathway

Postnatal immune activation leads to social deficits in a mouse model of TSC by abnormal interferon production in microglia.

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